What is Proton Therapy for Cancer Treatment?

Proton therapy is an advanced form of radiation therapy treatment that uses a single beam of high-energy protons to treat various forms of cancer. Just as with traditional radiation (x-ray/IMRT), protons treat tumors by directing radiation into the tumor site, where doses of radiation destroy cancerous cells. However, unlike x-rays, protons have the unique ability to stop directly at their target, depositing the maximum amount of radiation into the tumor while avoiding unnecessary radiation to nearby healthy tissue and vital organs. This reduces the risk of side effects during and after proton therapy treatment, compared to traditional radiation therapy treatment.

How Proton Therapy Works

When doses of protons enter the body, they deposit most of their energy at a specific target, destroying cancerous cells and reducing damage to surrounding areas and critical organs.  This differs from traditional radiation therapy treatment, which uses x-rays that have a higher entrance and exit dose both before and after the tumor.

To further explain, take a look at the graph below, and imagine that the Y-axis (radiation dose) is the surface of a patient’s skin, and the area between the dotted line is a tumor. The goal of radiation therapy treatment is to deliver the proper dose of radiation directly to the tumor while limiting the amount of exposure to surrounding healthy tissue. The sloping gray area shows how x-rays deliver a dose. To deposit the proper amount of energy into the tumor, conventional x-rays must irradiate much of the healthy tissue in front of it, and by their nature they continue to penetrate through the tumor and irradiate.

Both traditional radiation therapy treatment (x-ray/IMRT) and proton therapy attack tumors by preventing cancer cells from dividing and growing. Conventional radiation therapy uses x-rays which enter and exit the body, potentially causing damage to the healthy tissue that surrounds the tumor being treated.  Proton therapy targets the tumor with precise accuracy, allowing patients to receive higher, more effective doses, and reducing damage to nearby healthy tissue.

Provision CARES Proton Therapy features Pencil Beam Scanning (PBS), which increases the accuracy and advantages of the proton therapy treatment. With PBS, oncologists can treat a tumor using the proton beam at a precisely configured range and adjust the intensity of the beam to achieve the appropriate dose, then stop the beam in its tracks, limiting the collateral damage. As a result, vital organs surrounding the cancer are better protected from unnecessary radiation, thus minimizing or completely avoiding treatment-induced side effects, such as nerve damage with resulting neurologic dysfunction, as well as avoiding other complications such as breathing difficulties, feeding tubes, nausea, impotence, secondary cancers and more.

A non-invasive procedure, proton therapy as an advanced form of radiation therapy treatment is best used to treat individuals with a localized tumor, where cancer has not spread to other parts of the body; when tumors cannot be removed surgically; or in some cases when radiation therapy is required in addition to surgery. Proton therapy may be combined with other treatment options, depending on the specific details of your case.

Pencil Beam Scanning Technology

PBS technology has truly revolutionized proton therapy, offering increased flexibility in dose shaping and improved dose conformality, enabling clinicians to treat larger and more complex tumors. With PBS, a proton beam spot moves by magnetic scanning, while the beam intensity is adapted simultaneously, so that protons are delivered to one specific spot about the size of a dry-erase marker tip within the patient’s body. Previous proton radiation therapy treatment methods delivered the dose to the entire site at one time, making it difficult to accommodate for variations in tumor structure or volume. Pencil beam scanning reduces the radiation dose by 25 percent when compared to existing methods of proton delivery.

PBS also allows for a number of additional tumor sites to become candidates for proton therapy, including tumors of the lung, liver, breast, esophagus, pelvis, large sarcomas, high-risk prostate, and mediastinal tumors as well as re-irradiation of recurrent tumors, expanding the percentage of cancers that were considered good candidates for proton therapy from 20-30 percent to 80 percent. Large and non-contiguous targets benefit especially from PBS proton therapy. PBS also allows clinicians to sculpt doses to the complex shape of an individual tumor, which is ideal when treating tumors next to critical structures.

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