Proton Benefits

Clinical Studies

The body of strong, clinical evidence illustrating the benefits of proton therapy continues to grow. Provision and other medical centers participate in many ongoing clinical trials and research initiatives to expand our understanding of the disease sites for which proton therapy is the best treatment option and the benefits it gives different patient populations. Many proton therapy trials have been completed and have yielded compelling results.

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Prostate Cancer

Clinical Benefits of Proton Therapy:

  • Proton patients are almost twice as likely to report treatment had NO IMPACT on their quality of life compared to surgery, conventional radiation, and brachytherapy
  • 4.9% higher overall 5-year survival rate
  • 35% less radiation to bladder and 59% less radiation to the rectum
  • Half as many incidents of long term (2+ years) moderate or severe bowel problems
  • 42% reduction in relative risk of developing a secondary malignancy
  • Significantly fewer reports of gastrointestinal, genitourinary, endocrine, or “other” complications

Sources and Studies:

Dose–Volume Comparison of Proton Therapy and Intensity-Modulated Radiotherapy for Prostate Cancer.  Read More

Comparative Effectiveness Study of Patient-Reported Outcomes following Proton Therapy or IMRT for Prostate Cancer.  Read More

Early Outcomes from Three Prospective Trials of Image-Guided Proton Therapy for Prostate Cancer.   Read More

Erectile Function, Incontinence, and Other Quality of Life Outcomes Following Proton Therapy for Prostate Cancer in Men 60 Years Old and Younger.  Read More

Multi-Institutional Phase II Study of Proton Beam Therapy for Organ-Confined Prostate Cancer Focusing on the Incidence of Late Rectal Toxicities.  Read More

Randomized trial comparing conventional-dose with high-dose conformal radiation therapy in early-stage adenocarcinoma of the prostate: long-term results from proton radiation oncology group/American college of radiology 95-09.  Read More

Patient-Reported Long-term Outcomes After Conventional and High-Dose Combined Proton and Photon Radiation for Early Prostate Cancer.  Read More

Proton Therapy Coverage for Prostate Cancer Treatment.  Read More

Breast Cancer

Clinical Benefits of Proton Therapy:

  • 50% reduction of clinically significant radiation doses to the heart
  • Delivers 8-18 times less overall radiation to the heart than IMRT
  • 50-83% less risk of heart attack or another major coronary event depending on age
  • 97% of partial breast irradiation patients experience no breast tumor recurrence at 5 years
  • 90% of cases result in good to excellent cosmetic outcomes at 5 years

Sources and Studies:

Partial breast radiation therapy with proton beam: 5-year results with cosmetic outcomes.  Read More

Partial breast irradiation delivered with proton beam: results of a phase II trial.  Read More

A Technique of Partial Breast Irradiation Utilizing Proton Beam Radiotherapy: Comparison with Conformal X-Ray Therapy.  Read More

Accelerated partial breast irradiation using proton beams: Initial dosimetric experience.  Read More

Pragmatic Randomized Trial of Proton vs. Photon Therapy for Patients with Non-Metastatic Breast Cancer: A Radiotherapy Comparative Effectiveness (RADCOMP) Consortium Trial.  Read More

Lung Cancer

Clinical Benefits of Proton Therapy:

  • Higher radiation dose to the tumor while reducing risks of overall side effects
  • 56% reduction in incidences of grade 3 esophagitis
  • 50% reduction in relative risk of recurrence

Sources and Studies:

Proton Beam Radiotherapy and Concurrent Chemotherapy for Unresectable Stage III Non–Small Cell Lung Cancer – Final Results of a Phase 2 Study.  Read More

The clinical case for proton beam therapy.  Read More

Brain/Head and Neck Cancers

Clinical Benefits of Proton Therapy:

  • Less side effects during first 3 months after treatment, quicker return to normal function
  • 50% less likelyto have secondary tumor from treatment
  • 45% reduction in overall risk of needing a feeding tube for nasopharyngeal cancer
  • 27% reduction in overall risk of needing a feeding tube for oropharyngeal cancer
  • 44% increase of relative 5-year disease free survival rate for nasal and paranasal sinus cavity cancers
  • 50% overall increase of disease control for chordomas

Sources and Studies:

Proton Therapy Reduces Treatment Related Toxicities for Patients with Nasopharyngeal Cancer: A Case-Match Control Study of Intensity-Modulated Proton Therapy and Intensity-Modulated Photon Therapy.  Read More

Gastrostomy Tubes Decrease by Over 50% With Intensity Modulated Proton Therapy (IMPT) During the Treatment of Oropharyngeal Cancer Patients: A Case–Control Study.  Read More

Charged particle therapy versus photon therapy for paranasal sinus and nasal cavity malignant diseases: a systematic review and meta-analysis.  Read More

Effectiveness and Safety of Spot Scanning Proton Radiation Therapy for Chordomas and Chondrosarcomas of the Skull Base: First Long-Term Report.  Read More

Intensity-Modulated Proton Therapy (IMPT) versus Intensity-Modulated Photon Radiotherapy (IMRT) for Oropharyngeal Cancer: First Comparative Results of Patient-Reported Outcomes.  Read More

Impact of robust treatment planning on single- and multi-field optimized plans for proton beam therapy of unilateral head and neck target volumes.  Read More

Esophageal Cancer

Clinical Benefits of Proton Therapy:

  • 3 to 4-day reduction in average hospital stay
  • 1-22.8% overall reduction in pulmonary complications
  • 68% relative reduction in wound complications

Sources and Studies:

Radiation Modality Use and the Incidence of Postoperative Complications and Length of Hospitalization After Trimodality Therapy for Esophageal Cancer: A Multi-institutional Analysis.  Read More

Rectal/Anal Cancers

Clinical Benefits of Proton Therapy:

  • More than 50% reduction in radiation dose to critical structures including bone marrow

Sources and Studies:

Scanning proton beam therapy reduces normal tissue exposure in pelvic radiotherapy for anal cancer.  Read More

Current status and perspective of heavy ion beam therapy for patients with pelvic recurrence after primarily resected rectal cancer.  Read More

Liver Cancer (Hepatocellular)

Clinical Benefits of Proton Therapy:

  • 58% higher overall survival rate (2 years)

Sources and Studies:

The clinical benefits of proton therapy compared to conventional radiation treatments.  Read More

The safety and efficacy of high-dose proton beam radiotherapy for hepatocellular carcinoma: a phase 2 prospective trial.  Read More

Phase II study of radiotherapy employing proton beam for hepatocellular carcinoma.  Read More

Bile Duct

Clinical Benefits of Proton Therapy:

  • 54% higher overall survival (4 years)

Sources and Studies:

The clinical benefits of proton therapy compared to conventional radiation treatments.  Read More

Central Nervous System (CNS) Cancers

Sources and Studies:

Phase I/II Trial of Hyperfractionated Concomitant Boost Proton Radiotherapy for Supratentorial Glioblastoma Multiforme.  Read More

Phase II study of high-dose photon/proton radiotherapy in the management of spine sarcomas.  Read More

Combined proton and photon irradiation for craniopharyngioma: long-term results of the early cohort of patients treated at Harvard Cyclotron Laboratory and Massachusetts General Hospital.  Read More

Spinal cord tolerance to high-dose fractionated 3D conformal proton-photon irradiation as evaluated by equivalent uniform dose and dose volume histogram analysis.  Read More

Proton beam therapy in the management of central nervous system tumors in childhood: the preliminary experience of the Centre de Protonthérapie d’Orsay.  Read More

Dose-escalation with proton/photon irradiation for Daumas-Duport lower-grade glioma: results of an institutional phase I/II trial.  Read More

Ocular Malignancies and Benign Conditions

Sources and Studies:

The effectiveness and safety of proton radiation therapy for indications of the eye: a systematic review.  Read More

Proton beam irradiation for neovascular age-related macular degeneration.  Read More

Analysis of ocular surface alterations following proton beam radiation in eyes with conjunctival malignant melanoma.  Read More

Proton or stereotactic photon irradiation for posterior uveal melanoma? A planning intercomparison.  Read More

Clinical application of proton beams in the treatment of uveal melanoma: the first therapies carried out in Italy and preliminary results (CATANA Project).  Read More

Laser and proton radiation to reduce uveal melanoma-associated exudative retinal detachments.  Read More

Proton therapy for exudative age-related macular degeneration: a randomized, sham-controlled clinical trial.  Read More

Thoracic Malignancies and Non-small Cell Lung Cancers

Sources and Studies:

Proton SBRT for medically inoperable stage I NSCLC.  Read More 

Adaptive/Nonadaptive Proton Radiation Planning and Outcomes in a Phase II Trial for Locally Advanced Non-small Cell Lung Cancer.  Read More 

Early findings on toxicity of proton beam therapy with concurrent chemotherapy for nonsmall cell lung cancer.  Read More 

Comparisons of dose-volume histograms for proton-beam versus 3-D conformal x-ray therapy in patients with stage I non-small cell lung cancer.  Read More 

Hypofractionated high-dose proton beam therapy for stage I non-small-cell lung cancer: preliminary results of a phase I/II clinical study.  Read More 

High-dose proton beam therapy for Stage I non-small –cell lung cancer.  Read More 

Effects of proton and combined proton/photon beam radiation on pulmonary function in patients with resectable but medically inoperable non-small cell lung cancer.  Read More 

Pancreatic Cancer

Sources and Studies:

Modern radiation therapy techniques for pancreatic cancer.  Read More 

Treatment of locally advanced pancreatic cancer: the role of radiation therapy.  Read More 

Phase I study of preoperative short-course chemoradiation with proton beam therapy and capecitabine for resectable pancreatic ductal adenocarcinoma of the head.  Read More 

The role of proton therapy in the treatment of large irradiation volumes: a comparative planning study of pancreatic and biliary tumors.  Read More 

Bladder Malignancies

Sources and Studies:

A bladder preservation regimen using intra-arterial chemotherapy and radiotherapy for invasive bladder cancer: a prospective study.  Read More 

Cervical Malignancies

Sources and Studies:

Accelerated hyperfractionated radiotherapy for cervical cancer: multi-institutional prospective study of forum for nuclear cooperation in Asia among eight Asian countries.  Read More 

Image-guided radiotherapy for cervix cancer: high-tech external beam therapy versus high-tech brachytherapy.  Read More 

Long-term results of proton beam therapy for carcinoma of the uterine cervix.  Read More 

Sarcomas (Soft tissue)

Sources and Studies:

Randomized trial of proton vs. carbon ion radiation therapy in patients with low and intermediate grade chondrosarcoma of the skull base, clinical phase II study.  Read More 

Non-randomized therapy trial to determine the safety and efficacy of heavy ion radiotherapy in patients with non-resectable osteosarcoma.  Read More 

Pediatric Cancers and Malignancies

Sources and Studies:

Proton-Beam Therapy and Health-Related Quality of Life in Children With CNS Tumors.  Read More 

Proton Radiotherapy for solid tumors of childhood.  Read More 

Proton versus photon radiotherapy for common pediatric brain tumors: comparison of models of does characteristics and their relationship to cognitive function.  Read More 

Proton radiotherapy for childhood ependymoma: initial clinical outcomes and dose comparisons.  Read More 

Proton therapy in pediatric skull base and cervical canal low-grade bone malignancies.  Read More 

Evaluation of propofol for repeated prolonged deep sedation in children undergoing proton radiation therapy.  Read More 

Proton radiotherapy in management of pediatric base of skull tumors.  Read More 

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