Welcome to Provision CARES Proton Therapy Knoxville

Provision CARES Proton Therapy Knoxville opened its doors to patients on January 20, 2014.  We have treated over 2500 patients from all over the world, with a diversity of tumor sites.  Our 98% Patient Satisfaction scores speak to our excellence in patient experience and our Culture of Care.  The Provision CARES Cancer Campus offers comprehensive services for oncology, surgery, immunotherapy, conventional radiation, clinical trials, wellness center, and a clinical dietitian, all situated on a beautifully landscaped campus featuring a walking trail.

Provision CARES Proton Therapy Knoxville, a member of the Provision CARES Cancer Network, was the 13th proton center in the United States, the second in the Southeast, and the first in the state of Tennessee.  We are recognized in the industry for our innovative treatment protocols and clinical trials.

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APEx Accredited

Our 2017 APEx Accreditation from ASTRO (American Society of Radiation Oncology) distinguishes us from other cancer centers globally.  We were the first facility in Tennessee to be accredited and the first private practice/community-based proton facility to be accredited.

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Your Treatment Center

Provision CARES Proton Therapy Center is located in the heart of Knoxville, Tennessee, just a stone’s throw away from beautiful lakes and picturesque mountains.

Your Care Team

The Provision CARES Proton Therapy team is comprised of leading specialists, clinicians and experts with more than 50 years of physician and imaging oncology experience.

Lodging and Accomodations

The Tennessee community welcomes patients, caregivers and families to the area while you visit or stay for treatment.

Things to Do

Rolling mountains. Picturesque lakes. Entertainment and vibrant nightlife. East Tennessee provides the perfect backdrop for exploration and new experiences during your stay with us.

Contact a Care Coordinator

To get more info or schedule an appointment, visit the contact page or call today to speak with one of our Care Coordinators





Proton Ambassadors

Provision CARES Proton Therapy Knoxville formed the original Proton Ambassador Program in November 2012, with over sixty enthusiastic former proton therapy patients in the East Tennessee area, who had been treated at other proton centers domestically and globally. These former patients helped shape patient programs and many other things that would help future patients treated at Provision CARES Proton Therapy Knoxville, and the Provision CARES Cancer Network. Their genuine passion to help other patients was the driving force to the development of the program, which thrives at over 800 former proton patients today. Ambassadors volunteer to educate others, advocate for others, and most importantly, help those who have been recently diagnosed with cancer.

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Take Exit #383, Papermill Rd.
Turn right on Papermill Rd. and proceed to Weisgarber Rd. (first light)
Turn right on Weisgarber Rd. and proceed to Middlebrook Pk.
Turn left on Middlebrook Pk. and proceed to Dowell Springs Blvd. (second light)
Turn right on Dowell Springs Blvd.

Proceed to your second left.
Provision CARES Proton Therapy Center will be ahead on the right.
6450 Provision Cares Way
Knoxville, TN 37909

Take Exit #383, Papermill Rd.
Turn right on Weisgarber Rd. and proceed to Middlebrook Pk.
Turn left on Middlebrook Pk. and proceed to Dowell Springs Blvd. (second light)
Turn right on Dowell Springs Blvd. and proceed to your first left.

Proceed to your second left.
Provision CARES Proton Therapy Center will be ahead on the right.
6450 Provision Cares Way
Knoxville, TN 37909

Request Information

For information or to schedule a consultation, contact us to speak with a Care Coordinator.

Partner With Us

For general information or to learn about our collaborative partnerships, future developments, ProNova proton therapy system, or investment opportunities, contact us.