Proton Therapy Clinical Studies

1. Ares C, Hug EB, Lomax AJ, et al. Effectiveness and safety of spot scanning proton radiation therapy for chordomas and chondrosarcomas of the skull base: first long-term report. Int J Radiat Oncol Biol Phys. 2009;75(4):1111-1118. doi:10.1016/j.ijrobp.2008.12.055
2. Dennis ER, Bussiere MR, Niemierko A, et al. A comparison of critical structure dose and toxicity risks in patients with low grade gliomas treated with IMRT versus proton radiation therapy. Technol Cancer Res Treat. 2013;12(1):1-9. doi:10.7785/tcrt.2012.500276
3. Arvold ND, Niemierko A, Broussard GP, et al. Projected second tumor risk and dose to neurocognitive structures after proton versus photon radiotherapy for benign meningioma. Int J Radiat Oncol Biol Phys. 2012;83(4):e495-e500. doi:10.1016/j.ijrobp.2011.10.056
4. Frank S, Rosenthal DI, Ang K, et al. Gastrostomy Tubes Decrease by Over 50% With Intensity Modulated Proton Therapy (IMPT) During the Treatment of Oropharyngeal Cancer Patients: A Case–Control Study. Int J Radiat Oncol Biol Phys. 2013;87(2):S144. doi:10.1016/j.ijrobp.2013.06.371
5. Sio TT, Lin HK, Shi Q, et al. Intensity Modulated Proton Therapy Versus Intensity Modulated Photon Radiation Therapy for Oropharyngeal Cancer: First Comparative Results of Patient-Reported Outcomes. Int J Radiat Oncol Biol Phys. 2016;95(4):1107-1114. doi:10.1016/j.ijrobp.2016.02.044
6. Holliday EB, Garden AS, Rosenthal DI, et al. Proton Therapy Reduces Treatment-Related Toxicities for Patients with Nasopharyngeal Cancer: A Case-Match Control Study of Intensity-Modulated Proton Therapy and Intensity-Modulated Photon Therapy. Int J Part Ther. 2015;2(1):19-28. doi:10.14338/IJPT-15-00011.1
7. Romesser PB, Cahlon O, Scher E, et al. Proton beam radiation therapy results in significantly reduced toxicity compared with intensity-modulated radiation therapy for head and neck tumors that require ipsilateral radiation. Radiother Oncol. 2016;118(2):286-292. doi:10.1016/j.radonc.2015.12.008
8. Patel SH, Wang Z, Wong WW, et al. Charged particle therapy versus photon therapy for paranasal sinus and nasal cavity malignant diseases: a systematic review and meta-analysis. Lancet Oncol. 2014;15(9):1027-1038. doi:10.1016/S1470-2045(14)70268-2
9. Bekelman JE, Lu H, Pugh S, et al. Pragmatic randomised clinical trial of proton versus photon therapy for patients with non-metastatic breast cancer: the Radiotherapy Comparative Effectiveness (RadComp) Consortium trial protocol. BMJ Open. 2019;9(10):e025556. Published 2019 Oct 15. doi:10.1136/bmjopen-2018-025556
10. Cuaron JJ, Chon B, Tsai H, et al. Early toxicity in patients treated with postoperative proton therapy for locally advanced breast cancer. Int J Radiat Oncol Biol Phys. 2015;92(2):284-291. doi:10.1016/j.ijrobp.2015.01.005
11. Bush DA, Do S, Lum S, et al. Partial breast radiation therapy with proton beam: 5-year results with cosmetic outcomes. Int J Radiat Oncol Biol Phys. 2014;90(3):501-505. doi:10.1016/j.ijrobp.2014.05.1308
12. Hong TS, Wo JY, Yeap BY, et al. Multi-Institutional Phase II Study of High-Dose Hypofractionated Proton Beam Therapy in Patients With Localized, Unresectable Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma. J Clin Oncol. 2016;34(5):460-468. doi:10.1200/JCO.2015.64.2710
13. Higgins KA, O’Connell K, Liu Y, et al. National Cancer Database Analysis of Proton Versus Photon Radiation Therapy in Non-Small Cell Lung Cancer. Int J Radiat Oncol Biol Phys. 2017;97(1):128-137. doi:10.1016/j.ijrobp.2016.10.001
14. Chang JY, Verma V, Li M, et al. Proton Beam Radiotherapy and Concurrent Chemotherapy for Unresectable Stage III Non-Small Cell Lung Cancer: Final Results of a Phase 2 Study [published correction appears in JAMA Oncol. 2017 Sep 1;3(9):1286] [published correction appears in JAMA Oncol. 2017 Dec 1;3(12):1742]. JAMA Oncol. 2017;3(8):e172032. doi:10.1001/jamaoncol.2017.2032
15. Bush DA, Cheek G, Zaheer S, et al. High-dose hypofractionated proton beam radiation therapy is safe and effective for central and peripheral early-stage non-small cell lung cancer: results of a 12-year experience at Loma Linda University Medical Center. Int J Radiat Oncol Biol Phys. 2013;86(5):964-968. doi:10.1016/j.ijrobp.2013.05.002
16. Xi M, Xu C, Liao Z, et al. Comparative Outcomes After Definitive Chemoradiotherapy Using Proton Beam Therapy Versus Intensity Modulated Radiation Therapy for Esophageal Cancer: A Retrospective, Single-Institutional Analysis. Int J Radiat Oncol Biol Phys. 2017;99(3):667-676. doi:10.1016/j.ijrobp.2017.06.2450
17. Lester SC, Lin SH, Chuong M, et al. A Multi-institutional Analysis of Trimodality Therapy for Esophageal Cancer in Elderly Patients. Int J Radiat Oncol Biol Phys. 2017;98(4):820-828. doi:10.1016/j.ijrobp.2017.02.021
18. Fang P, Shiraishi Y, Verma V, et al. Lymphocyte-Sparing Effect of Proton Therapy in Patients with Esophageal Cancer Treated with Definitive Chemoradiation. Int J Part Ther. 2018;4(3):23-32. doi:10.14338/IJPT-17-00033.1
19. Lin SH, Merrell KW, Shen J, et al. Multi-institutional analysis of radiation modality use and postoperative outcomes of neoadjuvant chemoradiation for esophageal cancer. Radiother Oncol. 2017;123(3):376-381. doi:10.1016/j.radonc.2017.04.013
20. Hartsell W, Bentefour H, Dooling D, Mendenhall N. Proton Therapy is Associated with Superior Survival and Decreased Risk of Complications Compared to IMRT for Intermediate Risk Prostate Cancer: A Medicare/SEER Database Study. Proceedings to the 4th Annual Conference of the Particle Therapy Cooperative Group North America (PTCOG-NA), Abstract 34. Int J Part Ther. 2018;4(4):47-109. doi:10.14338/IJPT.18-PTCOG-2.1
21. Bryant Research. Awareness and Impressions of Selected Prostate Cancer Treatment Options Survey. 2013. Read More
22. Vargas C, Fryer A, Mahajan C, et al. Dose-volume comparison of proton therapy and intensity-modulated radiotherapy for prostate cancer. Int J Radiat Oncol Biol Phys. 2008;70(3):744-751. doi:10.1016/j.ijrobp.2007.07.2335
23. Hoppe BS, Michalski JM, Mendenhall NP, et al. Comparative effectiveness study of patient-reported outcomes after proton therapy or intensity-modulated radiotherapy for prostate cancer. Cancer. 2014;120(7):1076-1082. doi:10.1002/cncr.28536
24. Pan HY, Jiang J, Hoffman KE, et al. Comparative Toxicities and Cost of Intensity-Modulated Radiotherapy, Proton Radiation, and Stereotactic Body Radiotherapy Among Younger Men With Prostate Cancer. J Clin Oncol. 2018;36(18):1823-1830. doi:10.1200/JCO.2017.75.5371
25. Anand A, Bues M, Rule WG, et al. Scanning proton beam therapy reduces normal tissue exposure in pelvic radiotherapy for anal cancer. Radiother Oncol. 2015;117(3):505-508. doi:10.1016/j.radonc.2015.10.027
26. Chung CS, Yock TI, Nelson K, et al. Incidence of Second Malignancies Among Patients Treated With Proton Versus Photon Radiation. Int J Radiation Oncol Bio Physician. 2013;87(1):46-52. doi:10.1016/j.ijrobp.2013.04.030
27. Bryant C, Smith TL, Henderson RH, et al. Five-Year Biochemical Results, Toxicity, and Patient-Reported Quality of Life After Delivery of Dose-Escalated Image Guided Proton Therapy for Prostate Cancer. Int J Radiat Oncol Biol Phys. 2016;95(1):422-434. doi:10.1016/j.ijrobp.2016.02.038
28. Press Ganey Associates. Total mean score for consultation and graduation surveys combined. Medical Practice Survey. 2020 Jan 1 – 2021 Jun 30.
29. Baumann BC, Mitra N, Harton JG, et al. Comparative Effectiveness of Proton vs Photon Therapy as Part of Concurrent Chemoradiotherapy for Locally Advanced Cancer. JAMA Oncol. 2020;6(2):237-246. doi:10.1001/jamaoncol.2019.4889
30. Taylor CW, Wang Z, Macaulay E, Jagsi R, Duane F, Darby SC. Exposure of the Heart in Breast Cancer Radiation Therapy: A Systematic Review of Heart Doses Published During 2003 to 2013. Int J Radiat Oncol Biol Phys. 2015;93(4):845-853. doi:10.1016/j.ijrobp.2015.07.2292
31. Lin LL, Vennarini S, Dimofte A, et al. Proton beam versus photon beam dose to the heart and left anterior descending artery for left-sided breast cancer. Acta Oncol. 2015;54(7):1032-1039. doi:10.3109/0284186X.2015.1011756